Of course!
Step 1: Set up the inputs for 2 different games, 1: An arcade game with preferably 3 or more buttons, we will use "Golden Axe (set 6, US, 8751 317-123A), 2: A Neo-Geo game, how about "Cyber-Lip (NGM-010)"
Step 2: Load up the arcade game that is set up and go to inputs (F5), click "Save Preset"
Step 3: On the first pulldown select "Player 1", now click "Make Default"
At this point, these settings will be used for every game loaded after this point.
Neo-Geo & Megadrive uses different button names, so now its time to do some editing.
Go into "FBAlpha Folder\config\presets" and edit preset.ini. Also go into "FBAlpha Folder\config\games" and edit cyberlip.ini
You will then want to copy the buttons A-D for player 1 from the cyberlip.ini into preset.ini right under the last entry for P1, in this case will be "P1 Fire 3"
Save preset.ini with the new changes and your done.
best regards,
- dink